Single and multiple switches, swap and retransitioning among 28,073 biological drug users with inflammatory bowel diseases: results from the Italian VALORE network.

ABSTRACT:

Background

The increasing availability of biological drugs (originators and biosimilars) in the last decade for inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC), has led to complex switching patterns in real-world settings.

Objectives

To describe the switching/swapping patterns of biological drugs in IBD patients in Italy over the last decade.

Design

A retrospective cohort study was conducted using administrative data from 14 Italian regions (2010-2023) in the VALORE distributed database network.

Methods

Patients with at least 1 year of look-back and follow-up, who initiated biological therapy with ⩾2 dispensations for IBD, were included. Switches, swaps (between biologic classes), multiple switches (⩾2), switch-backs,

SUBMITTER: Pellegrini G 

PROVIDER: S-EPMC12477396 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature