Toward Noninvasively Imaging pH at the Surface of Implanted Orthopedic Devices in Live Rabbits Using X-ray Excited Luminescence Chemical Imaging.

ABSTRACT: X-ray excited luminescence chemical imaging (XELCI) and associated sensor surfaces are designed to noninvasively study, detect, and monitor local chemistry at the surface of modified implanted medical devices during infection. Implants are coated with polymer films containing scintillators and pH indicator dyes that together generate a pH-dependent luminescence when irradiated by X-rays. A focused X-ray beam provides high spatial resolution, while the pH indicator provides chemical sensitivity. A live rabbit pH-imaging study on a scintillator-coated implanted titanium plate evaluates the sensor performance with and without Staphylococcus aureus infection and biocompatibility through long-term histological examinations. 5000 cfu are sufficient to cause infection without fatality. XELCI imag

SUBMITTER: Uzair U 

PROVIDER: S-EPMC12477567 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature