Biomimetic, Suturable, and Extensible Electrospun Scaffolds for Lower Urinary Tract Surgical Reconstruction.

ABSTRACT: Common autologous tissue sources used for the repair or replacement of lower urinary tract (LUT) organs include the inner cheek (buccal), small and large bowels, and foreskin. These sources have limited availability, introduce the risk of donor site complications, and differ mechanically and biologically from LUT tissue. To address this, fibrous composite scaffolds with varying ratios of two naturally derived polymers-gelatin methacryloyl and an elastin-like peptide-are fabricated via electrospinning and photo-crosslinking. Among the tested ratios, 5:5% (w/v) elastin-like peptide-gelatin methacryloyl (5E5G) fibrous scaffolds are suturable and most closely replicate LUT tissue, exhibiting a tensile modulus of 25.6 ± 4.77 kPa, an ultimate tensile strength of 41 ± 6.68 kPa, and an elongation

SUBMITTER: Sturm RM 

PROVIDER: S-EPMC12477578 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature