Graded Hydroxyapatite Triply Periodic Minimal Surface Structures for Bone Tissue Engineering Applications.

ABSTRACT: Porous scaffolds in bone tissue engineering (BTE) play a crucial role in facilitating osteointegration with host tissues and providing nutrients to cells involved in bone healing. Scaffold architecture influences osteointegration, biofunctionality and mechanical strength, necessitating a clear understanding of its impact. In this study, hydroxyapatite scaffolds are 3D printed with three types of triply periodic minimal surface (TPMS) structures: gyroid, lidinoid, and split-P, at porosities ranging from 50% to 80%. Split-P architecture exhibits the highest compression strength, between 15 and 25 MPa, but provides the least surface area for bone apatite precipitation. Conversely, gyroid and lidinoid structures demonstrate the highest levels of bone apatite precipitation across all porosities

SUBMITTER: Koushik TM 

PROVIDER: S-EPMC12477579 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature