Porous Decellularized Nerve Grafts Facilitate Recellularization and Nerve Regeneration in a Rat Model of Critical Long-Gap Peripheral Nerve Injury.

ABSTRACT: Severe peripheral nerve injury (PNI) requiring nerve graft remains a clinical challenge due to limitations associated with currently available grafts. While decellularized nerve grafts (DNGs) are commonly used, their efficacy is largely restricted to short-gap repairs due to their acellular and dense structure, which poses a persistent challenge in the treatment of critical long-gap nerve defects. It is hypothesized that making porous DNGs (PDNGs) can create a suitable microenvironment that would facilitate the cell infiltration, recellularization, and further axonal growth to enhance nerve regeneration. In this study, PDNGs are generated and their ability are evaluated to support cell proliferation and penetration in vitro. Their potential to promote nerve regeneration in vivo using a rat

SUBMITTER: Alimi OA 

PROVIDER: S-EPMC12477580 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature