Associations Between Blunted Pupillary Constriction and Dilation in Individuals with Schizophrenia: Evidence of a Common Mechanism?

ABSTRACT:

Background and hypothesis

Unpacking the pathophysiological mechanisms of schizophrenia is necessary for advancing prediction, prevention, and treatment efforts. Mechanisms can be identified using easy-to-use and scalable clinical biomarkers, which reflect illness processes. Pupillometry is one such biomarker. Blunted dilation related to cognitive demand has been interpreted as a metric of diminished effort in schizophrenia, while blunted constriction to light has been interpreted as a metric of altered autonomic balance in schizophrenia. However, these 2 sets of findings may also reflect a common mechanism of schizophrenia. Therefore, this study aimed to explore the association between blunted cognitive dilation and blunted constriction to light to provide a parsimonious mechanism

SUBMITTER: Delay C 

PROVIDER: S-EPMC12477605 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature