A Bayesian analysis of diagnostic timelines across Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditions.

ABSTRACT:

Introduction

Timely diagnosis is crucial for managing neurodegenerative conditions. This study investigated whether time from symptom onset to diagnosis differs by clinical syndrome and sex.

Methods

This retrospective, cross-sectional study included 591 participants with Alzheimer's disease (AD), frontotemporal dementia (FTD) subtypes (behavioral variant FTD [bvFTD], semantic dementia [SD], and progressive non-fluent aphasia), logopenic progressive aphasia (LPA), and syndromes associated with movement disorders (corticobasal syndrome, FTD with motor neuron disease [FTD-MND], and progressive supranuclear palsy). Bayesian regression models were used to compute diagnostic timelines.

Results

Compared to AD (3.35 years; 95% credible interval [CrI]: 3.03-3.72), SD and bvFTD

SUBMITTER: Ambikairajah A 

PROVIDER: S-EPMC12477622 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature