Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration.

ABSTRACT:

Introduction

Current literature presents conflicting results regarding the impact of neuroinflammation on Alzheimer's disease (AD)-related neurodegeneration. While some studies suggest that neuroinflammation potentiates neurodegeneration, others indicate a protective effect.

Methods

We evaluated 145 individuals with positron emission tomography (PET) for amyloid beta (Aβ), tau, and translocator protein (TSPO), a proxy of neuroinflammation, to test the hypothesis that Aβ and tau are associated with the dual effect of neuroinflammation on neurodegeneration across the AD continuum.

Results

The detrimental effects of neuroinflammation on gray matter density occurred in two waves. The first neuroinflammation-related detrimental wave was associated with brain Aβ deposition,

SUBMITTER: Povala G 

PROVIDER: S-EPMC12477628 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature