More Than Rapid Eye Movement Sleep Behavior Disorder: Sleep Differences in Parkinson's Disease LRRK2 and GBA Genotypes.

ABSTRACT:

Objectives

Sleep disorders can significantly worsen the quality of life in Parkinson's disease (PD). Variants in LRRK2 and GBA1, the most common genetic contributors to PD, may lead to different clinical features, including more REM sleep behavior disorder (RBD) in PD associated with GBA1 mutations (GBA PD). However, there is a dearth of information about differences in non-RBD sleep disorders among these genetic subgroups.

Methods

Seventy-nine participants with PD (18 LRRK2 G2019S carriers with PD [LRRK2 PD], 22 GBA1 [GBA PD], 2 LRRK2 GBA PD and 37 idiopathic PD [iPD]) underwent actigraphy (Actiwatch-2) for 1 week. Subjective sleep quality was assessed using questionnaires.

Results

LRRK2 PD partici

SUBMITTER: Wise A 

PROVIDER: S-EPMC12477666 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature