An activator of phosphatidylinositol 3-kinase alpha restores cardioprotection from ischaemia/reperfusion injury in mice with coronary atherosclerosis or insulin resistance.

ABSTRACT:

Aims

In patients with coronary artery disease (CAD), morbidity and mortality from myocardial infarction remain high. Cardioprotective strategies such as remote ischaemic conditioning (RIC) are highly effective in animal models but have disappointed in large clinical trials. One explanation may be that ischaemia and reperfusion (I/R) experiments are typically conducted in mice that lack CAD. Unlike most mouse models, double-mutant SR-BIΔCT/ΔCT;Ldlr KO mice do develop CAD when fed a high-fat diet (HFD). The aim of this study was therefore to use these mice to investigate cardioprotection in the setting of CAD. We hypothesized that RIC, which requires cell-surface receptor signalling, would be ineffective in these mice; but that UCL-TRO-1938, a phosphatidylinositol 3-kinase alpha (PI3

SUBMITTER: Golforoush P 

PROVIDER: S-EPMC12477676 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature