The loss of microRNA-26b promotes aortic calcification through the regulation of cell-specific target genes.

ABSTRACT:

Aims

Vascular calcification is the abnormal deposition of calcium phosphates within blood vessels. This condition is significantly associated with the development of cardiovascular disease, yet the underlying mechanisms remain largely unknown. MicroRNAs (miRNAs) may be crucial in initiating vascular calcification by regulating a network of specific cellular targets. In this study, we explored for the first time the potential role of microRNA-26b (miR-26b) in vascular calcification.

Methods and results

Using micro-positron emission tomography and computed tomography (micro-PET/CT) imaging with 18F-sodium fluoride, we measured aortic calcification in miR-26b knockout mice (miR-26bKO). We conducted bulk RNA sequencing (RNA-seq), single-cell RNA sequencing, and network analysis

SUBMITTER: Luna Buitrago D 

PROVIDER: S-EPMC12477678 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature