Relationships Between Intra-Spinal Resting-State Functional Connectivity and Electrophysiology Following Spinal Cord Injury.

ABSTRACT: We previously reported that a unilateral dorsal column lesion (DCL) at the cervical C4 level primarily reduces inter-horn resting-state functional connectivity (rsFC) measured by functional Magnetic Resonance Imaging (fMRI) in segments below the lesion. This study compares changes in rsFC from fMRI with changes in local field potential (LFP) coherence over an extended post-injury period. High-resolution fMRI and LFP data were acquired bilaterally in healthy monkeys and at 3- and 6-months post-lesion. At 3 months post-injury, tactile-stimulus-evoked LFP power in the dorsal horn was significantly weaker than in the healthy cord and non-lesion side. LFP coherences increased on the lesion side for the dorsal-to-intermediate zone (D-IGM) and dorsal-to-ventral (D-V) pairs but decreased for the n

SUBMITTER: Yang PF 

PROVIDER: S-EPMC12477704 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature