Examining effective monotherapy hypothesis for TB therapy failure and resistance emergence.

ABSTRACT: We tested the hypothesis that because of the different metabolic states of Mycobacterium tuberculosis (Mtb) in lesions, drugs in combination therapy often act effectively as monotherapy, leading to therapy failure and resistance emergence.Bactericidal and sterilizing activity studies were performed in the hollow fiber system of TB (HFS-TB) using the human equivalent dose of isoniazid (INH) 300 mg/day, rifampin (RIF) 600 mg/day, and pyrazinamide (PZA) 1.5 g/day either as monotherapy, two-, and three-drug combination for 28 days. The Mtb population (log₁₀ CFU/ml) for each drug, either monotherapy or combination, was compared using an analysis of variance.In the bactericidal activ

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC12477726 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature