Tolerance of high fibre supplementation among participants in a randomised trial to reduce cancer risk among Alaska Native peoples: Alaska FIRST.

ABSTRACT: Describing the epidemiology of colorectal cancer (CRC), Burkitt (1971) emphasised the increased incidence among developed, industrial populations consuming a more refined diet and proposed dietary fibre as the key to the lower CRC incidence noted in underdeveloped countries with less refined diets. Noting the increased incidence of CRC among Alaska Native (AN) peoples and seemingly low presence of fibre in some AN diets, investigators with the University of Pittsburgh and the Alaska Native Tribal Health Consortium proposed to test whether large amounts of fibre contained in a dietary supplement could lower CRC risk. We describe supplement tolerance as reported by AN participants completing a 4-week supplementation trial, which added 44.5 grams per day (g/d) total fibre (23.7 g/d resistant

SUBMITTER: Koller KR 

PROVIDER: S-EPMC12477768 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature