Post-COVID-19 disruption of the respiratory microbiome modulates <i>Mycoplasma pneumoniae</i>: a multi-center retrospective investigation study.

ABSTRACT: Since the COVID-19 pandemic, there has been a notable resurgence of Mycoplasma pneumoniae pneumonia (MPP) in children, with a concerning rise in the severity of cases. Although changes in post-pandemic respiratory infection patterns have been documented, the reasons behind the increased severity of MPP, especially concerning shifts in the respiratory microbiota, are not well understood. This study aims to explore how pandemic-associated disruptions in respiratory microbiota contribute to MPP severity. Through analysis of multiple independent cohorts, we found that the depletion of protective respiratory microbiota exacerbates MPP severity by reducing colonization resistance against M. pneumoniae. We identified two antagonistic microbiota modules with distinct metabolic featur

SUBMITTER: Huang S 

PROVIDER: S-EPMC12477775 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature