VH032 suppresses glioma proliferation by inhibiting the VHL/HIF-1α/VEGF pathway.

ABSTRACT:

Purpose

VH032 is a VHL ligand employed for the recruitment of the von Hippel-Lindau (VHL) protein. Recent studies reveal VHL exhibits significant antitumour effects on various tumor cells. Nevertheless, VH032's impacts on glioma cells remain largely unexplored.

Methods

The study explored VH032's impact on glioma cell lines U87MG and U251 through a series of experimental assessments. The experiments included cell viability assays, wound healing assays and transwell assays. The apoptotic activity of VH032 was determined via flow cytometry. Finally, a xenograft tumor model composed of nude mice was used to confirm the results.

Results

In vitro, the CCK-8 assay indicated that VH032 potently inhibited the proliferation of glioma cells. Wound healing and transwell assays fu

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12477846 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature