SNHG16 promotes breast cancer progression by regulating the hsa-let-7b-5p/AURKA axis.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) play crucial roles in the progression of breast cancer (BC). The lncRNA small nuclear RNA host gene 16 (SNHG16), represents a lncRNA associated with tumor development. This study focuses on SNHG16 and its regulatory role in BC progression, validated through microarray analysis and in vitro experiments.

Method

The GEO datasets GSE65194 and GSE61304 were used to identify differentially expressed lncRNAs, GSE41922 and GSE45666 for differentially expressed miRNAs, and GSE29431 and GSE42568 for differentially expressed mRNAs. The TCGA database was used to validate the genes identified in the previous analyses. The regulatory pathways of SNHG16 were identified through differential gene analysis, target gene prediction, functional enrichmen

SUBMITTER: Qiao Z 

PROVIDER: S-EPMC12477852 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature