Development of a PRAME pMHC targeted T cell engager for solid tumor therapy.

ABSTRACT: Bispecific T cell engager (TCE) therapies have demonstrated transformative clinical success in the treatment of hematological cancers, but the lack of antigens that are sufficiently selective for malignant cells has hampered the success of TCEs in the solid-tumor space. To overcome the on-target, off-tumor toxicities that result from the expression of even low levels of tumor-associated antigens in healthy tissues, we sought to identify a TCE target with highly tumor-restricted expression patterns. Here, we characterize cancer-testes antigen Preferentially Expressed Antigen in Melanoma (PRAME) as a highly selective tumor antigen and identify a proteasomal degradation peptide PRAME_425-433 (PRAME₄₂₅) presented in the context of major histocompatibility complex I (MHCI)

SUBMITTER: Skrzypczynska K 

PROVIDER: S-EPMC12477861 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature