Serum 25 (OH) D levels and risk of female-specific cancer in premenopausal women: a prospective study.

ABSTRACT:

Background

Serum 25 (OH) D levels are associated with various diseases, including cancers, but inconsistencies exist for female-specific malignancies. This study is aimed to explore the real relationship between serum 25 (OH) D levels and incidence rates of female specific cancers in premenopausal women by a large-scale prospective cohort study.

Study design

We analyzed data from 51,286 UK Biobank participants using Cox regression models to explore associations. Subgroup analyses were based on vitamin D supplementation, alcohol, smoking, BMI, diabetes, sleep, and outdoor exposure. Categorical variables were described by frequencies and compared with chi-squared tests.

Results

During a median follow-up of 13.8 years, all cancer incidence was 5.1% (n = 2,614), wi

SUBMITTER: Hu Y 

PROVIDER: S-EPMC12477915 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature