Unveiling <i>Chlamydia trachomatis</i> immunity in urogenital secretions: A systematic review.

ABSTRACT: Chlamydia trachomatis (CT) is a highly prevalent bacterial sexually transmitted infection (STI), associated with severe disease complications. CT targets a unique immunological environment: the genital tract epithelium. Although sampling the genital tract is challenging, previous studies have shown that genital CT-specific antibodies exhibit enhanced neutralizing capacity compared with serum antibodies. Furthermore, tissue-resident memory T (TRM) cells provide superior protection compared with circulating T cells. However, further research is required to identify correlates of protection and explore correlations between local and systemic responses. This review provides an overview of the sampling methods suitable for identifying mucosal immune biomarkers associated with CT infectio

SUBMITTER: Van Caesbroeck A 

PROVIDER: S-EPMC12478110 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature