Association between Early Pregnancy Maternal Folate and Glycemic Indices at Oral Glucose Tolerance Test: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Folate plays a crucial role in fetal development, but its relationship with maternal glucose metabolism remains inconclusive. Recent meta-analyses have suggested a correlation between high folate and risk of gestational diabetes mellitus in pregnancy; however, its association with different glycemic parameters has not yet been explored.

Objectives

This study aims to comprehensively synthesize evidence and test the association between early pregnancy circulating folate (<16 wk of gestation) and glycemic indices measured during oral glucose tolerance testing (OGTT) at 24-28 wk.

Methods

We conducted a systematic search of databases up to 25 June, 2025, examining the relationship between early pregnancy folate and maternal glycemic indices. Study quality was as

SUBMITTER: Periyathambi N 

PROVIDER: S-EPMC12478247 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature