Elevated FBXO45 promotes TFG ubiquitination and drives lung metastasis of hepatocellular carcinoma.

ABSTRACT:

Background & aims

Elevated F-box/SPRY domain protein 1 (FBXO45) expression is associated with human hepatocellular carcinoma (HCC). While TP53 mutations represent a common genetic alteration in HCC, the potential regulatory interplay between TP53 and FBXO45 in modulating HCC progression remains unclear.

Methods

We analyzed the relationship between TP53 and FBXO45 in patients with HCC. A series of assays were also performed to explore the effect of FBXO45 on invasion and metastasis in TP53-mutated HCC cell lines and mouse models. These experimental findings were further validated in clinical samples.

Results

FBXO45 expression was upregulated in 78.3% (83/106) of patients with HCC with TP53 mutation, marking an aggressive subtype. Overexpression of FBXO45 significantly

SUBMITTER: Zhu ZB 

PROVIDER: S-EPMC12478254 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature