Retreatment TB is a risk factor for multidrug-resistant TB among people with HIV in rural eastern Uganda: A nested case-control study.

ABSTRACT:

Rationale

People with human immunodeficiency virus (PWH) have an increased risk of multidrug-resistant TB (MDR-TB) compared to those without HIV.

Objective

To investigate the risk factors for MDR-TB among PWH in rural eastern Uganda.

Methods

We conducted a nested case-control study at Soroti Regional Referral Hospital in rural eastern Uganda. TB records from January 2017 to May 2024 were retrospectively reviewed to identify all PWH. MDR-TB was defined as resistance to at least both Isoniazid and Rifampicin following GeneXpert Mycobacterium TB and Rifampicin assay and culture-based drug-susceptible testing. Cases were PWH with MDR-TB, while controls were a random sample of PWH without MDR-TB, in a 1:3 ratio. Multivariable binary logistic regression was used to i

SUBMITTER: Opolot G 

PROVIDER: S-EPMC12478262 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature