Plasma neurology-related proteins associated with cognition are modulated by lifestyle in adults.

ABSTRACT:

Background

Cognitive decline (CD) is an age-related process exacerbated by metabolic syndrome (MetS), which may be mitigated by lifestyle interventions. Plasma biomarkers hold promise for early CD detection, but prospective evidence is limited. Therefore, we aimed to prospectively determine associations between peripheral neurology-related proteins and CD, and to assess whether the lifestyle intervention of the PREDIMED-Plus trial could modify these associations.

Methods

A 6-year observational study including 314 PREDIMED-Plus participants with overweight/obesity and MetS (mean age: 65 years, 44% women) were randomised to an intensive weight-loss intervention or a control group. At baseline and 3-year follow-up, plasma neurological and inflammatory proteins were quantified u

SUBMITTER: Margara-Escudero HJ 

PROVIDER: S-EPMC12478270 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature