Identification of potential therapeutic targets for problematic alcohol use using multi-omics data.

ABSTRACT:

Background

Problematic alcohol use (PAU) is a serious global health issue with limited treatment options. Although genetic studies have identified genomic regions associated with PAU, the specific causal genes and proteins remain unclear. This study aimed to identify these causal genes by integrating diverse genetic and molecular data to inform better treatment strategies.

Methods

We used Mendelian randomisation (MR) to identify genes and proteins that may cause PAU by combining genetic data with gene activity in brain and blood tissues. Multiple statistical tests confirmed shared genetic signals between expression and PAU. We also examined their effects on other traits and potential interactions with existing drugs.

Findings

We identified 97 genes and 13 proteins tha

SUBMITTER: Lee DJ 

PROVIDER: S-EPMC12478272 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature