Approach for systematically assessing study reliability and relevance in evaluations of monosodium glutamate safety.

ABSTRACT: Monosodium glutamate (MSG) is a well-studied food additive. In addition to numerous authoritative assessments of safety, a substantial volume of research is ongoing with MSG; this includes a growing volume of research assessing the ameliorating potential of various substances against purported MSG-induced toxicity. This work set out to develop an approach for evaluating the combined reliability and relevance of these types of investigations as part of ingredient safety assessments, and subsequently, to apply such to a case study of MSG publications involving co-exposures with other substances. The approach assesses the reliability of the studies utilizing SciRAP, and the relevance in context of study design, dose relevance, and biological validity, resulting in an overall categorization of

SUBMITTER: Klaren WD 

PROVIDER: S-EPMC12478279 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature