Impact of Donor and Recipient Sex on Long-Term Outcomes Following Living Donor Kidney Transplantation: A Retrospective Dual-Center Study.

ABSTRACT:

Background

The impact of donor and recipient sex on living donor kidney transplantation (LDKT) remains debated. This study investigates the impact of donor-recipient sex combinations on long-term transplant outcomes.

Methods

A dual-center retrospective study was conducted at Erasmus Medical Center (EMC) and University Medical Center Groningen (UMCG), including all LDKT patients between 2010 and 2020. Transplantations were categorized into male donor-male recipient (MDMR, n = 476), female donor-male recipient (FDMR, n = 765), male donor-female recipient (MDFR, n = 463), and female donor-female recipient pairs (FDFR, n = 372). The primary outcome was graft survival. Secondary outcomes included patient survival, delayed graft function (DGF), acute rejection, and graft function.

SUBMITTER: Fang Y 

PROVIDER: S-EPMC12478291 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature