USENSE: A proof-of-concept self-screening tool for home-based recurrent urinary tract infection management.

ABSTRACT: In this work, we report a novel proof-of-concept biosensing diagnostic tool for the multiplexed electrochemical quantitation of a unique combination of three UTI-relevant biomarkers, Prostaglandin E2 (PGE2), Interleukin-8 (IL-8), and Lipopolysaccharide (LPS), in unfiltered human urine. The proposed device, called USENSE, integrates lateral flow microfluidic channels, a gold-based sensor array for quantifying PGE2, IL-8, and LPS levels, and a random forest machine learning model for reliable diagnosis of UTI. The device is unique as it not only acts as a diagnostic device but also provides information on UTI by providing a risk score for UTI recurrence. USENSE is culture-free and label-free, requires no sample preparation at the user end, and can be adapted for use in home-based self-screen

SUBMITTER: Ganguly A 

PROVIDER: S-EPMC12478329 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature