Validation of a Mitochondrial Polygenic Score for Parkinson's Disease.

ABSTRACT:

Background

Mitochondrial dysfunction is a key player in Parkinson's disease (PD) pathogenesis. Mitochondrial polygenic scores (MGS) may be associated with PD but require validation across diverse populations.

Objective

To validate the association between the MGS, PD status and age-at-onset (AAO) in idiopathic and LRRK2-PD across various ancestries.

Methods

We analyzed data from 17,129 PD patients and 13,872 healthy individuals across 10 ancestries within the Global Parkinson's Disease Genetic Program. We used regression models to assess the association between MGS, PD status and AAO.

Results

The MGS was associated with iPD in Europeans (β=0.19, SE=0.02, p<2.0×10^-16) and Ashkenazi Jews (β=0.26, p=3.7×10^-4) but not in other population

SUBMITTER: Ern Ooi JC 

PROVIDER: S-EPMC12478347 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature