Angiogenic CD8 T cells from PWH induce Granzymes-dependent PAR1 activation promoting endothelial inflammation.

ABSTRACT: In people with HIV (PWH), T cell immune activation and endothelial inflammation are contributors of the increased cardiovascular risk, however the mechanisms remain poorly understood. PAR1 connects the coagulation cascade, endothelial cells and CD8 T cells at the site of endothelial inflammation and we hypothesized that HIV driven CD8 T cell immune activation alters endothelial repair mechanisms. Endothelial repair is partially mediated by angiogenic T (T_ang) cells that facilitate proliferation of endothelial cells, and differentiation of endothelial progenitor cells at site of vascular injury. During LCMV infection, we identified a subset of CD31^highCD8 T cells that exhibited a long-lived memory precursor phenotype (CD127⁺KLRG1^-) and secreted th

SUBMITTER: Li T 

PROVIDER: S-EPMC12478364 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature