Clinical predictors and incidence of Kaposi sarcoma among males with HIV in the Treat-all era in the United States and Canada.

ABSTRACT:

Background

Stagnating declines in Kaposi sarcoma (KS) among men with HIV (MWH) following Treat-All policies necessitate evaluating changes in clinical drivers of KS. We examined clinical factors and their associations with KS rates among MWH in North America.

Methods

Among MWH in the North American AIDS Cohort Collaboration on Research and Design, we estimated annual KS rates (per 100,000 person-years [PY]) by viral suppression (<200 copies/mL), CD4 count (<500 vs. ≥500 cells/mm3) and time since ART initiation (<1 year/naïve vs. ≥ 1 year) from 2009-2019. We quantified associations between clinical factors and KS rates using negative binomial regression, estimating incidence rate ratios with 95% confidence intervals (IRR, 95% CI). Among MWH with KS, we estimated average annua

SUBMITTER: Coburn SB 

PROVIDER: S-EPMC12478527 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature