The careful selection of zwitterionic nanoparticle coating results in rapid and efficient cell labelling for imaging-based cell tracking.

ABSTRACT: The increased clinical application of cell-based therapies has resulted in a parallel increase in the need for non-invasive imaging-based approaches for cell tracking, often through labelling with nanoparticles. An ideal nanoparticle for such applications must be biologically compatible as well as readily internalized by cells to ensure adequate and stable cell loading. Surface coatings have been used to make nanoparticle trackers suitable for these purposes, but those currently employed tend to have cytotoxic effects. Zwitterionic ligands are known to be biocompatible and antifouling, however the head-to-head evaluation of specific zwitterionic ligands for cell loading has not yet been explored. Magnetic particle imaging (MPI) detects superparamagnetic iron oxide nanoparticles (SPIONs) us

SUBMITTER: Calvert ND 

PROVIDER: S-EPMC12478535 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature