Manipulating memory processing during sleep to explore the critical duration of reactivation events.

ABSTRACT: Newly encoded memories are reactivated and consolidated during sleep. However, how the reactivation of a specific memory unfolds over time is poorly understood. What are the temporal dynamics of a single reactivation event within a period of sleep? Does extending a single reactivation opportunity translate to stronger memory benefits? We explored these dynamics by utilizing targeted memory reactivation (TMR), a technique that biases the consolidation of memories via the unobtrusive presentation of memory-associated cues during sleep. Participants learned the on-screen positions of sixty objects, each linked with a unique sound (e.g., cat - meow). Some sounds were then presented during non-REM sleep, with the duration allotted for reactivation causally controlled by varying the timing of th

SUBMITTER: Lazarus A 

PROVIDER: S-EPMC12478543 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature