Homologous Recombination Deficiency and Survival in Ovarian High-Grade Serous Carcinoma by Self-Reported Race.

ABSTRACT:

Background

Half of ovarian high-grade serous carcinomas (HGSC) have homologous recombination deficiency (HRD). However, HRD is not well characterized in Black individuals who experience worse survival after a diagnosis of HGSC. The objective of this study was to characterize ovarian HGSC HRD and examine its association with survival by self-reported race.

Methods

HRD features were identified using matched tumor-normal whole-exome and RNA sequencing in an HGSC cohort. We calculated age- and stage-adjusted HR and 95% confidence intervals (CI) for survival, comparing individuals with a feature to those without, separately by self-reported race.

Results

Any HRD was associated with a 32% reduced risk of death in Black individuals compared with a 62% reduction in White indi

SUBMITTER: Lawson-Michod KA 

PROVIDER: S-EPMC12478560 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature