Chimeric PRR T-cell-engager targeting cell surface β-1,3-glucan for invasive candidiasis.

ABSTRACT: Invasive candidiasis, primarily caused by Candida albicans, represents the most common fungal disease among hospitalized patients and poses a significant threat to human health. Intrinsic or acquired immunosuppression serves as a critical risk factor predisposing individuals to this disease, while simultaneously reducing the efficacy of conventional antifungal therapies and worsening clinical outcomes. Given the central role of immune dysfunction in the pathogenesis of invasive candidiasis, immunotherapeutic strategies hold substantial promise. We targeted dectin-1, the primary pattern recognition receptor for β-1,3-glucan, by engineering XJ104, a bispecific T-cell engager that fuses dectin-1 to the light chains of an anti-CD3 monoclonal antibody. This construct is designed to bridge Candi

SUBMITTER: Sun YF 

PROVIDER: S-EPMC12478890 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature