Olfactory bulbectomy-induced impairment of lipid utilization leads to abnormal glucose metabolism in mice.

ABSTRACT: Increased lipid utilization after food odor perception is a recently identified Pavlovian cephalic phase response in fasted mice that serves to prevent diet-induced glucose intolerance. However, the impact of olfactory dysfunction on metabolic functions remains unclear. Since olfactory bulbectomized (OBX) rodents have been used as a model of irreversible complete anosmia, we investigated whether glucose, lipid, and energy metabolism change over time in OBX mice fed a normal chow diet (NCD) or high-fat diet (HFD). OBX caused constant hyperactivity and triphasic temporal changes in lipid and glucose metabolism. In the early stage, OBX disrupted the olfactory regulation of lipid utilization and reduced fasting serum fatty acid levels without affecting glucose tolerance. In the middle stage (1

SUBMITTER: Sugiyama M 

PROVIDER: S-EPMC12478900 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature