Effect of aspirin on grip strength and gait speed in community-dwelling older adults in the ASPirin in Reducing Events in the Elderly (ASPREE) Study.

ABSTRACT:

Background

Grip strength and gait speed are key markers of physical functional capacity and general health in older people. This study aimed to examine the effect of low-dose aspirin on handgrip strength and habitual gait speed in relatively healthy older people.

Methods

The ASPREE (ASPirin in Reducing Events in the Elderly) trial randomized 19 114 community-dwelling Australians and US adults aged 70+ years (US minorities ≥65 years) who were free of overt cardiovascular disease, dementia, and limitations in activities of daily living to daily 100 mg aspirin versus placebo. Linear mixed models were used to compare the effects of treatment groups on changes in grip strength and gait speed over time, and Cox proportional hazard models were used to compare time to incident grip

SUBMITTER: Phyo AZZ 

PROVIDER: S-EPMC12479048 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature