Liquid Plasma Induces Necroptosis Without Inflammatory Responses in Head and Neck Cancer Cells.

ABSTRACT:

Background

Several types of regulated cell deaths are known, including apoptosis, necroptosis, autophagy, ferroptosis, and pyroptosis. Among these types of cell deaths, apoptosis is induced by many cancer therapeutic agents. In the case of resistance, however, induction of other regulated cell death, such as necroptosis, are required. Liquid plasma, which is prepared by treatment of non-thermal plasma to solution, induces various types of regulated cell death via reactive oxygen and nitrogen species.

Methods

Liquid plasma was generated by N₂/Ar plasma treatment in culture medium (minimum essential medium (MEM), Dulbecco's modified Eagle medium (DMEM), or Roswell Park Memorial Institute (RPMI)-1640) for 120 s per milliliter of medium (2 cm). Cell viability was dete

SUBMITTER: Choi JH 

PROVIDER: S-EPMC12479077 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature