Versatile Polypeptide-Anchored Antifouling Dip-Coatings for Common Medical Implant Materials.

ABSTRACT: Implant-associated infections represent a critical global healthcare challenge, exacerbated by recalcitrant biofilm formation and rising antimicrobial resistance. While antifouling polymer coatings could deter bacterial adhesion, common grafting methods such as surface-initiated polymerization face scalability and regulatory challenges. Dip-coating of antifouling polymers, facilitated by catechol-mediated anchorage to common medical implants, serves as a translationally appealing alternative. Although 3,4-dihydroxyphenylalanine (DOPA)-lysine-based oligopeptides were shown to exhibit mussel adhesive-like properties, they are not suitable for tethering high-molecular-weight (MW) antifouling polymers required for achieving adequate surface coverage. To facilitate unbiased screening for robust

SUBMITTER: Nisal R 

PROVIDER: S-EPMC12479112 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature