Innate Lymphoid Cell Phenotypic and Functional Alterations in Patients With Systemic Juvenile Idiopathic Arthritis.

ABSTRACT:

Objective

Systemic juvenile idiopathic arthritis (sJIA) is a chronic childhood disease classically attributed to innate immune cell dysregulation. This study aimed to elucidate the role of innate lymphoid cells (ILCs), including natural killer (NK) cells and helper-ILCs (hILCs), in sJIA during clinically inactive disease (CID) through phenotypic and functional analysis.

Methods

Peripheral ILCs from children with sJIA during CID receiving interleukin-1 (IL-1) inhibitors (n = 40) were analyzed by flow cytometry and compared to 23 healthy children (HC) and 22 patients with unrelated autoinflammatory diseases taking IL-1 inhibitors. Plasma proteomic profiling was also performed.

Results

Patients with sJIA showed a significant reduction in circulating NK cell frequencies c

SUBMITTER: Quatrini L 

PROVIDER: S-EPMC12479180 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature