Effect of Long-Term Voclosporin Treatment on Renal Histology in Patients With Active Lupus Nephritis With Repeat Renal Biopsies.

ABSTRACT:

Objective

This study characterized the impact of voclosporin on kidney histology in patients with lupus nephritis (LN) who had protocolized repeat kidney biopsies in the AURORA clinical trials.

Methods

Patients were randomized to voclosporin or placebo treatment for up to 3 years; all patients received mycophenolate mofetil and low-dose glucocorticoids. Patients had baseline kidney biopsies within 6 months before study start and repeat biopsies after approximately 18 months of study treatment. The revised National Institutes of Health indices for LN activity and chronicity (CI) were calculated in addition to a semiquantitative assessment of vascular and tubular lesions.

Results

Sixteen patients in the voclosporin group and 10 patients in the control group had both bas

SUBMITTER: Rovin BH 

PROVIDER: S-EPMC12479183 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature