Platelet-to-high-density lipoprotein cholesterol ratio as a predictor of stroke risk: a longitudinal analysis of the China health and retirement longitudinal study.

ABSTRACT:

Background

Stroke is a major health concern in aging populations. This study investigates the platelet-to-high-density lipoprotein cholesterol ratio (PHR) as a predictor of stroke risk in middle-aged and older Chinese adults.

Methods

We analyzed data from 8,405 participants aged ≥45 years in the China Health and Retirement Longitudinal Study (CHARLS), with an 8-year follow-up. PHR was calculated from baseline blood samples. Multivariate logistic regression models, supplemented by smooth curve fitting to assess dose-response relationships and subgroup analyses with interaction testing, assessed the association between PHR and stroke incidence, adjusting for various factors.

Results

During follow-up, 753 (8.96%) participants reported a stroke. Smooth curve fitting visua

SUBMITTER: Feng Q 

PROVIDER: S-EPMC12479224 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature