Transcriptional profiles of vaccine-induced protection in bovine herpesvirus-1 and <i>Mycoplasma bovis</i>-challenged bison.

ABSTRACT:

Introduction

Mycoplasma bovis causes chronic respiratory disease with high mortality rates in American bison (Bison bison). A recent study showed that a subunit vaccine containing M. bovis elongation factor thermal unstable (EFTu) and heat shock protein 70 (Hsp70) antigens induced immunity and enhanced protection in bison, resulting in reduced lung lesions and bacterial loads following experimental M. bovis challenge. This study aimed to characterize the transcriptional responses underlying this protection in vaccinated (n = 5) compared to unvaccinated control (n = 4) bison following M. bovis infection.

Methods

Two doses of vaccines were administered on day 0 and at 21 days post-vaccination (DPV), followed by intranasal inocul

SUBMITTER: Goldkamp AK 

PROVIDER: S-EPMC12479254 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature