Volatile organic compounds exposure associated with frailty in United States adults from NHANES 2011-2018.

ABSTRACT:

Background

Whether environmentally relevant exposure to volatile organic compounds (VOCs) contributes to frailty remains unknown. We examined urinary VOC metabolites (VOCms) and their mixtures in relation to frailty in a nationally representative U.S. cohort.

Methods

We analysed 2,715 adults (≥ 20 y) from NHANES 2011-2018 in a cross-sectional design. Frailty was defined with a 48-item index. Sixteen creatinine-adjusted VOCms were quantified. Single metabolites were evaluated with survey-weighted logistic regression. Two-directional weighted-quantile-sum regression (WQS), grouped Bayesian kernel machine regression (BKMR) and quantile g-computation (qgcomp) characterized mixture effects, and sex- and age-stratified subgroup analyses were performed. Mediation by γ-glutam

SUBMITTER: Qu TZ 

PROVIDER: S-EPMC12479300 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature