Association of MIF rs1007888 and ARAP1 rs1552224 genetic variants with the risk of gestational diabetes mellitus in a chinese population; case study and meta-analysis.

ABSTRACT:

Background

Macrophage migration inhibitory factor (MIF) rs1007888 is significantly associated with pancreatic β-cell function and insulin resistance in patients with gestational diabetes mellitus (GDM). The ArfGAP with RhoGAP domain, ankyrin repeat, and PH domain-containing protein 1 (ARAP1) rs1552224 locus has been identified as a risk locus for type 2 diabetes, and recent reports have linked it to elevated blood glucose levels and reduced insulin release upon glucose stimulation. Few studies have been conducted on these genetic variants and their risk of GDM. This study aimed to investigate the association between these two genetic variants (ARAP1) rs1552224 and (MIF) rs1007888 and the risk of developing GDM.

Methods

A case-control study

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12479318 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature