Th17-associated cytokine gene hypomethylation reflects epigenetic dysregulation in graves' disease.

ABSTRACT:

Introduction

Graves' disease (GD) is an organ-specific autoimmune disorder characterized by the presence of thyroid-stimulating hormone receptor autoantibodies (TRAb), leading to hyperthyroidism. While genetic and environmental factors contribute to GD pathogenesis, the role of epigenetic mechanisms, particularly in regulating Th17-associated cytokines, remains poorly understood.

Methods

This study aimed to characterize the promoter methylation profiles of IL17, IL21, and IL22 in GD patients, evaluate their diagnostic potential, and explore correlations with clinical parameters. Targeted bisulfite sequencing was performed on peripheral blood mononuclear cells from 60 GD patients, including newly diagnosed and refractory individuals, and 60 matched healthy controls.

Result

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12479413 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature