Understanding mechanistic relationships between IgG titers and Fc effector functions: a computational framework to assess polyfunctionality.

ABSTRACT:

Introduction

Recent vaccine and infectious disease studies have highlighted the importance of antibodies that activate cellular Fc functions, including antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC), which are mediated by different Fc gamma Receptors (FcγRs). Activation of these functions requires complex overlapping interactions between IgG antibodies, FcγRs, and antigens that can be challenging to deconvolve experimentally.

Methods

Here we created an ordinary differential equation model that simultaneously predicted FcγRIIIa immune complexes upstream of ADCC and FcγRIIa immune complexes upstream of ADCP as a function of antigen, IgG, and FcγR concentration and binding properties. We then used the model to dissect mechani

SUBMITTER: Shoffner-Beck SK 

PROVIDER: S-EPMC12479434 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature