Cell death mechanisms induced by gold nano-immunoconjugates-mediated photodynamic therapy against human oesophageal cancer stem cells.

ABSTRACT:

Background

The current conventional therapy for oesophageal cancer is unable to effectively eliminate oesophageal cancer cells as a result of cancer stem cells (CSCs). These CSCs are the main factors responsible for treatment failure and tumour relapse associated with the present conventional oesophageal cancer therapy. A nano-immunoconjugate-based photodynamic therapy (PDT) proposes a potential approach to eliminate these CSCs efficiently.

Method

In this study, we examined the mode of cell death action induced by the nano-immunoconjugates (NIC) mediated PDT comprising aluminium phthalocyanine tetra sulfonic acid chloride (AlPcS₄Cl), gold nanoparticles (AuNPs), and anti-CD271 antibody (AlPcS₄Cl-AuNPs-anti-CD271) against human oesophageal CSCs in vitr

SUBMITTER: Didamson OC 

PROVIDER: S-EPMC12479469 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature