Utilizing group-based models to identify adverse event patterns after an intervention.

ABSTRACT:

Background

Standard adverse event (AE) monitoring only records whether events occur after the intervention, and not whether these events vary over time.

Objective

To test whether there were statistically distinct time-varying trajectories of AE (e.g., "side effects") after an intervention and identify characteristics of individuals associated with these patterns.

Design

Group-based trajectory models applied to an observational study of individuals who received one or two doses of a mRNA COVID-19 vaccine (i.e., the intervention).

Participants

50,484 healthcare personnel who received their vaccinations within the Mass General Brigham (MGB) healthcare system.

Interventions

Vaccination.

Main measures

Allergic and non-allergic AE for 1-3 days after eac

SUBMITTER: Wang W 

PROVIDER: S-EPMC12479506 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature