Qingda granule prevents Ang II-induced cardiac hypertrophy via inhibiting NF-κB signaling pathway.

ABSTRACT:

Background

Angiotensin II (Ang II) type 1 receptor (AT1R) signaling pathway is a key component of the renin-angiotensin-aldosterone system (RAAS) that is involved in the development of hypertension. Chronic Ang II overactivation results in pathological cardiac hypertrophy that progresses into decompensated cardiac dysfunction and impairment. Qingda granule (QDG) is a Traditional Chinese formula that has been used clinically in treating hypertension and its complications.

Purpose

This study aimed to elucidate the role and underlying mechanisms of QDG in preventing Ang II-induced cardiac hypertrophy.

Methods

We used chronic Ang II infusion via minipumps in mice and administered QDG daily to examine the effects of QDG on preventing hypertension and various parameters of

SUBMITTER: Gong Y 

PROVIDER: S-EPMC12479541 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature